Amanda Burkhardt, PhD
Faculty Directory

Amanda BurkhardtPhD

Amanda BurkhardtPhD

Assistant Professor of Clinical Pharmacy

Titus Family Department of Clinical Pharmacy

Prior to joining USC Mann faculty, Amanda M. Burkhardt was an adjunct assistant professor at the University of California, Irvine, in the School of Medicine, Department of Physiology & Biophysics; and lecturer in the Department of Biological Sciences at California State University, Long Beach. She holds a BS in microbiology from the University of California, San Diego, and a PhD in immunology from the University of California, Irvine.

Her research career has focused on the development of novel vaccines and adjuvants, discovery of cytokines and chemokines, and tuning immune responses to vaccine formulations using adjuvants based on Toll-like receptors and nanoparticles.

Since joining USC Mann School of Pharmacy, Dr. Burkhardt has launched Trojan CALM, a student led research project that measures stress in the university population through salivary cortisol testing and stress assessment surveys.

Dr. Burkhardt has lectured and mentored doctoral, undergraduate and medical students, developed engaging course curriculum, and authored multiple patents and journal articles based on her findings.

She is also co-director of the STAR program, a cooperative venture in science education between the USC Health Sciences Campus and Francisco Bravo Medical Magnet High School in East Los Angeles.

Areas of Expertise

  • Chemokines
  • Vaccine Immunology
  • Immunology
  • Vaccines
  • Cytokines
  • Cortisol
  • Stress
  • Innovative teaching methods
  • Education

    University of California, Irvine


    University of California, San Diego


  • Links
  • Selected Articles

    Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii

    The Journal of Immunology

    2019 Coxiella burnetii is an obligate intracellular bacterium and the causative agent of Q fever. C. burnetii is considered a potential bioterrorism agent because of its low infectious dose; resistance to heat, drying, and common disinfectants; and lack of prophylactic therapies. Q-Vax, a formalin-inactivated whole-bacteria vaccine, is currently the only prophylactic measure that is protective against C. burnetii infections but is not U.S. Food and Drug Administration approved.

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    CCL28 Is Involved in Mucosal IgA Responses, Olfaction, and Resistance to Enteric Infections

    Journal of Interferon & Cytokine Research

    2019 CCL28 is a mucosal chemokine that has been involved in various responses, including IgA production. We have analyzed its production in human tissues using a comprehensive microarray database. Its highest expression is in the salivary gland, indicating that it is an important component of saliva. It is also expressed in the trachea, bronchus, and in the mammary gland upon onset of lactation.

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    Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses

    American Chemical Society

    2019 Traditional vaccination strategies have failed to generate effective vaccines for many infections like tuberculosis and HIV. New approaches are needed for each type of disease. The protective immunity and distinct responses of many successful vaccines come from activating multiple Toll-like receptors (TLRs).

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    Identification of IL-40, a Novel B Cell–Associated Cytokine

    The Journal of Immunology

    2017 We describe a novel B cell-associated cytokine, encoded by an uncharacterized gene (C17orf99; chromosome 17 open reading frame 99), that is expressed in bone marrow and fetal liver and whose expression is also induced in peripheral B cells upon activation. C17orf99 is only present in mammalian genomes, and it encodes a small (∼27-kDa) secreted protein unrelated to other cytokine families, suggesting a function in mammalian immune responses.

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    Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17

    The Journal of Immunology

    2015 Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in the body. Chemokines bind to G protein–coupled receptors expressed on target cells to initiate signaling cascades and induce chemotaxis. Although the cognate receptors of most chemokines have been identified, the receptor for the mucosal chemokine CXCL17 is undefined. In this article, we show that GPR35 is the receptor of CXCL17.

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    METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages

    Clinical Immunology

    2014 Cytokines are involved in many functions of the immune system including initiating, amplifying and resolving immune responses. Through bioinformatics analyses of a comprehensive database of gene expression (BIGE: Body Index of Gene Expression) we observed that a small secreted protein encoded by a poorly characterized gene called meteorin-like (METRNL), is highly expressed in mucosal tissues, skin and activated macrophages.

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    Homeostatic chemokine receptors and organ-specific metastasis

    Nature Reviews Immunology

    2011 Evidence that homeostatic chemokines determine metastatic destinations has come from mouse models, in which blocking certain homeostatic chemokine receptors blocks metastasis, and from retrospective human studies, in which the expression of a chemokine receptor is associated with metastasis to a given organ and/or poor prognosis.

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  • Affiliations
    • Member, Association for Women in Science: 2008 to present

    • Member, The American Association of Immunologists: 2012 to present

    • Member, Federation of Clinical Immunologists: 2013 to present

    • Board Member, Science Ambassador Scholarship: 2020 to present

    • Member, Society for the Advancement of Biology Education Research (SABER)