Evaluating the impact of obesity on safety and efficacy of weight-based norepinephrine dosing in septic shock: A single-center, retrospective study
Intensive and Critical Care Nursing
Wong PJ, Pandya KA, and Flannery AH
2017
Norepinephrine is the first-line vasopressor recommended for patients in septic shock. Weight-based dosing may increase drug exposure and the risk of adverse effects in obese patients. The objective was to evaluate the safety and efficacy of weight-based norepinephrine dosing using actual body weight in the morbidly obese compared with normal weight patients.
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Four-factor prothrombin complex concentrate-associated hypotension
The American Journal of Emergency Medicine
Wong PJ, Bailey AM, and Baum RA
2016
Warfarin is a vitamin K antagonist used to treat patients with hypercoagulable disease states but increases the risk of life-threatening bleeding. Prothrombin complex concentrate has been recommended if these bleeds occur. Kcentra, a 4-factor prothrombin complex concentrate, has been Food and Drug Administration approved for the urgent reversal of vitamin K antagonist–associated major bleeding. Hypotension has been reported with Kcentra use, but limited information is available about these reactions.
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Accumetrics-based clopidogrel dosing in endovascular neurosurgery
Neurological Research
Wong P, Tesoro E, Aletich V, and Alaraj A
2015
The role of the VerifyNow test to guide clopidogrel therapy in neurosurgical patients is still unclear. This study compared outcomes in patients undergoing neurointerventional procedures on either standard clopidogrel or tailored clopidogrel regimens.
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